The RADIOTRANSNET project is a French initiative for the structuration of preclinical research in the field of radiation oncology in France. It has been submitted by the French Society of Radiation Oncology (SFRO) and the French society of medical physics (SFPM). It has been favorably evaluated by the International Evaluation Committee of INCa (the French Cancer Institute). RADIOTRANSNET network has officially been launched at the end of 2018.

Research and Innovation in optimized medical applications of ionizing radiation aim to improve patient care and quality of life. The ambition of RADIOTRANSNET is to propose a robust methodology of science-based consensus aiming 1) to build a national research consortium dedicated to radiation oncology, 2) to implement a strategic research agenda (SRA) based on rigorous scientific and medical state of the art in radiotherapy and radiobiology, and 3) to define a road map to favor existing scientific and clinical interactions.

Four main strategies (4 workpackages) have been identified to improve therapeutic index of radiotherapy and define RADIOTRANSNET network activities:

• WP1: Optimizing the specificity of the dose distribution of radiotherapy treatments,
• WP2: Decreasing radiotherapy side effects on normal tissue,
• WP3: Combining new molecular targeted agents and biological modifiers,
• WP4: Optimizing dose modelling and treatment planning

This third RadioTransNet Workshop is dedicated to the Workpackage 2 of the projet and aims defining strategies to better understand the impact of ionising radiations on tumor surronding normal tissue in order to prevent radiotherapy side effects. Indeed, adverse effects affecting normal tissue can result in acute and chronic toxicities that reduce the long-term health-related quality of life of patients. Despite considerable progress towards reducing toxicity of radiation therapy have been made by the introduction of so-called “dosesculpting” treatment techniques, new insights into the underlying pathophysiology have to
strengthen the understanding of the mechanisms of combined tissue-induced toxicity, new diagnostic strategies and management opportunities. Preclinical research investigating mechanistic processes of normal tissue response are required to optimize radiation exposure

This Workshop aims, through several oral presentations, to draw up an inventory of current practices and emerging methods in order to address the key issues and to identify the needs. Then, a “working groups” session will allow reflections and exchanges to start the structuration process in order to define an adapted research program within the RadioTransNet Network.

Registration

Registration is free but mandatory to attend the workshop.

The deadline for registration is december 5^th, 2019.

To attend this workshop, please proceed to the registration using the online form.

You can already contribute to working groups submitting an abtract. Summaries may include research priorties, short programm, existing collaborations (academic and/or industrial) or any suggestion related to round tables issues.

Looking forward to seeing you,

The RadioTransNet team.